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Introduction (movie) Introductory movie to the tutorial and how to use it.

Lay Tutorial

The Cell

The Cell A short lay tutorial about eukaryotic cells covering the membrane, the cytoplasm and the nucleus.

Gene Expression

Gene Expression An overview of gene expression covering transcription, translation and protein modification.

Genetic Code A short lecture about the genetic code and how it translates into protein.

Mutation What is a mutation. What is a silent, dominant and a recessive mutation.

Transcription A simple overview of the mechanism of mRNA synthesis.

Translation The mechanism of protein synthesis.

Protein Modification Protein modification is explained here using the RAS model (Prenylation).

Advanced Tutorial

The Cell Cycle

The Mammalian Cell Cycle (animated) Overview of the cell cycle from G1- to M-phase.

CDK (animated) Introduction to cyclin dependent kinases. Regulation of CDKs, in particular CDK2, CDK4 and 6 by CKIs (p21kip, p27kip, p57kip, p16ink) and by CDK7, WEE1 and CDC25.

G1-phase (animated) Introduction to proteins important for G1-phase: CDK2 and 4, Retinoblastoma protein pRb, E2F and CDK inhibitors p16 and p27.

G1-phase Regulation How is the G1-phase progression regulated in normal and deregulated in cancer cells. Emphasis of this lesson is the CDK4/6 regulation.

Gamma-irradiation The role of the tumor suppressor p53 and the CDK inhibitor p21.

DNA repair

This is a link to an excellent animated tutorial on another web site about ATR kinase and DNA repair. (advanced tutorial)

Drug Targets

Drug/Treatment Tutorial (animated) Introduction to cancer treatments and overview of chemotherapy (drugs, antibodies, antisense).

Hallmarks of Cancer

Hallmarks of Cancer (animated) An introduction to some basics of Cancer Biolgy: Tumor suppressor genes, Oncogenes, Immortalization, Transformation, Contact inhibition.

Signal Transduction

Introduction (animated) Introduction to Signal Transduction, the principals, in normal and cancer cells, History (Retroviruses).

Methodology: cDNA array - Microarray

NEW! (Flash-XML file) This is an example for a cDNA or microarray presentation showing actual data. This file has sound.